Callum Wilson, Jeff Hendrick and Jamal Lewis will make their Magpies debuts in Newcastle United's opening game of the 2020/21 Premier League season at West Ham United (kick-off 8pm BST).
The trio, who all joined the club during the brief close season, are named in Steve Bruce's starting XI at the London Stadium while fellow new boys Ryan Fraser and Mark Gillespie start on the bench.
England international Wilson is partnered up front by Andy Carroll, who faces his former club after an impressive pre-season, with Allan Saint-Maximin making up a varied and exciting front three.
Former Burnley man Hendrick is joined in midfield by Isaac Hayden, who signed a new six-year contract with club on Friday, and Jonjo Shelvey, who scored both home and away against the Hammers last season.
Ex-Norwich full-back Lewis is at left-back, with Javier Manquillo on the right side of defence and Federico Fernández and skipper Jamaal Lascelles in the centre.
Martin Dúbravka's injury means that Karl Darlow makes his first Premier League appearance since a 1-1 draw at Crystal Palace in February 2018. The 29-year-old goalkeeper has played a number of cup games in the meantime and agreed a new five-year deal on Friday.
Fraser, whose last Premier League match came for AFC Bournemouth in March, will wait in the wings should Bruce require added impetus later in the game. Also on the bench are Gillespie, Emil Krafth, Matt Ritchie, Sean Longstaff, Miguel Almirón and Joelinton
Newcastle United: Karl Darlow; Javier Manquillo, Federico Fernández, Jamaal Lascelles (c), Jamal Lewis; Jeff Hendrick, Isaac Hayden, Jonjo Shelvey; Callum Wilson, Andy Carroll, Allan Saint-Maximin.
Substitutes: Mark Gillespie, Emil Krafth, Matt Ritchie, Sean Longstaff, Ryan Fraser, Miguel Almirón, Joelinton