Tonali - who missed the 1-0 Premier League win at Chelsea on Saturday through illness - trained with the rest of the United squad in the Spotify Camp Nou on Tuesday evening and has been deemed fit enough to start in Catalonia as Howe's men chase a place in the quarter-finals.

Kieran Trippier and Dan Burn will also line-up against the five-time winners of the competition, with Joelinton and Anthony Elanga also restored to the side.

Aaron Ramsdale keeps his place in goal, with Lewis Hall, Malick Thiaw, Anthony Gordon, Harvey Barnes and Jacob Ramsey all retaining their spots after the victory at Stamford Bridge.

That means Tino Livramento, Sven Botman, Joe Willock, Jacob Murphy and Nick Woltemade all revert to the bench for the all-important clash with Hansi Flick's charges.

Yoane Wissa, Will Osula and Sean Neave are the other attacking reinforcements among the substitutes, while Alex Murphy is also named.

And there are three goalkeepers on the bench too, in the shape of Nick Pope, John Ruddy and Aidan Harris.

Newcastle United: Aaron Ramsdale, Kieran Trippier (c), Lewis Hall, Joelinton, Sandro Tonali, Anthony Gordon, Harvey Barnes, Malick Thiaw, Anthony Elanga, Dan Burn, Jacob Ramsey

Substitutes: Nick Pope, John Ruddy, Aidan Harris, Sven Botman, Yoane Wissa, Will Osula, Tino Livramento, Jacob Murphy, Nick Woltemade, Joe Willock, Alex Murphy, Sean Neave