The Magpies are back in domestic action after their 3-2 Champions League knockout phase play-off second leg win over Qarabağ in midweek - a result which set up a last 16 tie with Barcelona.
And head coach Howe has opted to shuffle his pack for the visit of David Moyes' men, with Nick Pope, Lewis Hall and Malick Thiaw all returning to the line-up.
Further forward, Jacob Ramsey, Anthony Elanga and Anthony Gordon are also back in from the start as United look for the win that would return them to the top half of the table.
Kieran Trippier, Joelinton and Sandro Tonali all keep their places after the 9-3 aggregate with over the Azerbaijani outfit last time out, with Nick Woltemade and Dan Burn also in the 11.
Six of the starters on Tuesday - Aaron Ramsdale, Alex Murphy, Sven Botman, Harvey Barnes, Jacob Murphy and Will Osula - are named on the bench for the clash with the Toffees, with Yoane Wissa, Joe Willock and Leo Shahar completing the list of substitutes.
Newcastle United: Nick Pope, Kieran Trippier (c), Lewis Hall, Joelinton, Sandro Tonali, Anthony Gordon, Malick Thiaw, Anthony Elanga, Nick Woltemade, Dan Burn, Jacob Ramsey
Substitutes: Aaron Ramsdale, Sven Botman, Yoane Wissa, Harvey Barnes, Will Osula, Jacob Murphy, Joe Willock, Alex Murphy, Leo Shahar




