Kieran Trippier and Harvey Barnes come into the starting XI in place of Emil Krafth and Jacob Murphy.

Skipper Bruno Guimarães has recovered sufficiently from illness to take his place in midfield as the Magpies look to make it three wins from four in the competition.

Anthony Gordon has scored in each of United's Champions League games so far and provides support for Nick Woltemade.

William Osula was initially named among the substitutes, but will no longer be involved due to discomfort in his ankle. He'll be assessed further in the coming days.

Newcastle have already eclipsed their points tally of five from their previous Champions League campaign in 2023/24 and a win against their La Liga opponents will see them match their best ever group stage tally of nine, set in 2002/03.

Newcastle United: Nick Pope, Kieran Trippier, Sven Botman, Joelinton, Sandro Tonali, Anthony Gordon, Harvey Barnes, Malick Thiaw, Nick Woltemade, Dan Burn, Bruno Guimarães (c)

Subs not used: Max Thompson, Aaron Ramsdale, Lewis Hall, Fabian Schär, Emil Krafth, Anthony Elanga, Jacob Murphy, Joe Willock, Alex Murphy, Jacob Ramsey, Lewis Miley