The Toon teenagers, who currently occupy third spot in the Under-18 Premier League North after winning six of their opening nine league fixtures, have been handed an away draw against the defending champions, who target a third FA Youth Cup title in four seasons.
Man City's youngsters also sit at the top of the Under-18 Premier League North, six points above the young Magpies, and have won their opening eight league fixtures, scoring 33 goals.
Should ties finish level after 90 minutes, 30 minutes of extra time will be played. If the scores remain level after this time, the result will be decided by a penalty shoot-out.
All ties are scheduled to be completed by Saturday, 12th December.
A date and kick-off time will be confirmed on newcastleunited.com at the earliest opportunity.
FA Youth Cup third round draw in full:
Bolton Wanderers v Tottenham Hotspur
Cheadle Town or Sheffield Wednesday v Southampton
Luton Town v Hertford Town or Cambridge United
Sunderland v Aston Villa
Sheffield United v Wolverhampton Wanderers
Norwich City v Preston North End
Fulham v Swansea City
Coventry City v Reading or Swindon Town
Stockport County or Blyth Spartans v Leicester City or Milton Keynes Dons
Shrewsbury Town or Fleetwood Town v Blackpool
Barnet or AFC Sudbury v Bristol Rovers or Oxford United
Lincoln City v Leeds United
Blackburn Rovers v Bradford City or Crewe Alexandra
West Ham United v Brentford
Plymouth Argyle or St Ives Town v Birmingham City
Portsmouth v Bromley or AFC Wimbledon
AFC Bournemouth v Solihull Moors or Barnsley
Everton v Nottingham Forest
Arsenal v Cardiff City
Queens Park Rangers v Middlesbrough
Ilkeston Town or Tranmere Rovers v Hull City
Ipswich Town v Liverpool
Wrexham v Cobham or Exeter City
Burnley v Manchester United
Grimsby Town or Chorley v Brighton & Hove Albion
Wycombe Wanderers or Leyton Orient v Wigan Athletic or Mansfield Town
Derby County v Chelsea
Stoke City v Charlton Athletic
Manchester City v Newcastle United
West Bromwich Albion v Watford
Crystal Palace v Millwall
Chippenham Town or Kingstonian v Bristol City
