United entertain the Reds on Tyneside, with tributes to Kevin Keegan - a legendary figure at both clubs - planned ahead of the 4.30pm BST kick-off.

And new head coach Jaissle has opted to give the trio their first tastes of top tier football at St. James' Park on what is also the German boss' first game in charge of the club.

Horníček is in goal, with Dedić lining up in defence alongside Malick Thiaw, who captains the side in the absence of Dan Burn, who misses out with an ankle injury sustained in training and is expected to be sidelined for a couple of weeks. Sven Botman also starts, as does Lewis Hall.

Teenage midfielder Steur partners Lewis Miley in the middle of the park, with Anthony Elanga and Harvey Barnes on the flanks and Yoane Wissa further forward alongside Will Osula.

Three more recent arrivals are among the substitutes, with Ewen Jaouen, Aladji Bamba and Bazoumana Touré all poised to make their Magpies bows from the bench.

Fabian Schär and Leo Shahar provide defensive cover, with Jacob Ramsey, Joe Willock and Jacob Murphy also backup options.

Forward Nick Woltemade is also named as Jaissle's side look to kick-off their campaign with a home win.

Former United frontman Alexander Isak is in the Liverpool line-up on his first return to St. James' Park since his departure in the summer of 2025.

Newcastle United: Lukáš Horníček, Lewis Hall, Sven Botman, Yoane Wissa, Will Osula, Harvey Barnes, Malick Thiaw, Sean Steur, Anthony Elanga, Amar Dedić, Lewis Miley

Substitutes: Ewen Jaouen, Fabian Schär, Aladji Bamba, Bazoumana Touré, Jacob Murphy, Nick Woltemade, Joe Willock, Jacob Ramsey, Leo Shahar