The Magpies target a seventh consecutive league win against the Clarets, who currently sit in the relegation zone under Scott Parker's management, and Howe has reshuffled his pack from Tuesday's 2-2 draw against Tottenham Hotspur.
Anthony Gordon, on target from the penalty spot against Spurs, is named in the starting 11 in place of Harvey Barnes, who drops to the bench, while Anthony Elanga, targeting his first Magpies goal since his move from Nottingham Forest last summer, replaces Jacob Murphy on the right wing.
Aaron Ramsdale continues in-between the sticks behind a four-man defence, with Fabian Schär likely to partner Malick Thiaw in the heart of United's defence while Dan Burn is set to line up at left-back in place of Lewis Hall.
Bruno Guimarães, who scored in Newcastle's 4-1 away win against Burnley during the 2023/24 season, captains the hosts this afternoon and will feature alongside Jacob Ramsey and Joe Willock in the middle of the park while Elanga and Gordon will aim to provide attacking support for Nick Woltemade, who has scored seven goals so far this season.
Wissa has been named in a Newcastle matchday squad for the first time as the DR Congo international aims to make his highly-anticipated Magpies bow following his transfer from Brentford in September.
Howe has a number of reinforcements to deploy from the bench if required, including Sandro Tonali, Joelinton and Lewis Miley, while John Ruddy is the substitute goalkeeper.
Newcastle United: Aaron Ramsdale, Fabian Schär, Anthony Gordon, Malick Thiaw, Anthony Elanga, Tino Livramento, Nick Woltemade, Joe Willock, Dan Burn, Bruno Guimarães (c), Jacob Ramsey.
Substitutes: John Ruddy, Lewis Hall, Joelinton, Sandro Tonali, Yoane Wissa, Harvey Barnes, Jacob Murphy, Alex Murphy, Lewis Miley.




