The skipper suffered an ankle injury against PSV in midweek and, although Eddie Howe pledged to "give him every chance" for the visit of the Villans, he is not named in the squad.
Miley will take his place in the only change to the team, with Joelinton making his 250th appearance for the Magpies alongside him. He will also move outright into the top ten of the club's all-time Premier League appearances chart with his 204th top-flight outing.
There are welcome returns to the squad for Dan Burn - back after puncturing a lung and fracturing a rib in at Sunderland last month - and William Osula, whose last appearance came at West Ham in early November due to an ankle problem.
Kieran Trippier is captain in the absence of Guimarães. Jacob Ramsey is on the bench against his former club.
Newcastle United: Nick Pope, Kieran Trippier (c), Lewis Hall, Sven Botman, Joelinton, Sandro Tonali, Yoane Wissa, Anthony Gordon, Harvey Barnes, Malick Thiaw, Lewis Miley
Substitutes: Aaron Ramsdale, William Osula, Anthony Elanga, Nick Woltemade, Joe Willock, Dan Burn, Alex Murphy, Jacob Ramsey, Leo Shahar




