The Spanish midfielder, who arrived on Tyneside from Manchester City earlier this week, is one of six changes from Wednesday's 3-2 win against West Bromwich Albion in the Carabao Cup.

Goalkeeper Lukáš Horníček, who made his Premier League debut in last week's 2-2 draw against Liverpool, replaces Ewen Jaouen in-between the sticks.

Head coach Matthias Jaissle has named an unchanged backline for a third consecutive game, with Malick Thiaw and Sven Botman situated at the heart of United's defence, while Amar Dedić and Lewis Hall are set to play on the respective flanks.

González, who made his Premier League bow against Newcastle in February 2025, will line up alongside Lewis Miley in the middle of the park.

Harvey Barnes, who netted a second half brace against West Brom, as well as Joe Willock and Anthony Elanga are named in the starting 11 as they aim to provide attacking support for Yoane Wissa, who has three goal involvements in his last three league outings against Spurs.

Jaissle has a number of options to deploy from the substitutes' bench if required, including Jacob Ramsey who netted the winning goal in last season's 2-1 victory at the Tottenham Hotspur Stadium.

Nick Woltemade, who scored in United's 2-0 win against Tottenham in the Carabao Cup last season, is also named on the bench as well as Bazoumana Touré, Jacob Muphy, Sean Steur and Aladji Bamba.

Fabian Schär and Leo Shahar, the latter targeting his Premier League debut, are defensive reinforcements.

Newcastle United: Lukáš Horníček, Lewis Hall, Sven Botman, Nico González, Yoane Wissa, Harvey Barnes, Malick Thiaw (c), Anthony Elanga, Joe Willock, Amar Dedić, Lewis Miley.

Substitutes: Ewen Jaouen, Fabian Schär, Aladji Bamba, Sean Steur, Bazoumana Touré, Jacob Murphy, Nick Woltemade, Jacob Ramsey, Leo Shahar.