Sean Steur and Joe Willock come in for Nico González and Amar Dedić, who are both ruled out, while it's a young bench for the Magpies.
Alongside 18-year-old Mason Miley - an unused substitute at Leeds on Monday night - are fellow Academy products Kyran Thompson, Miodrag Pivaš, Vakhtang Salia and Michael Mills.
Serbian defender Pivaš is the oldest at 21, and featured at first team level in pre-season. His senior experience includes a loan spell at Willem II in 2024/25. Mills and Thompson are both 17 while Salia, 19, joined United from Dinamo Tbilisi last year.
Read more about them type: entry-hyperlink id: nMhqiwsynz5r8rooMUlxV.
Tino Livramento is absent from the squad, while Dedić and González joined a growing list of players unavailable to Jaissle; William Osula, Joelinton, Anthony Elanga, Dan Burn and Ewen Jaouen are also sidelined.
Matias Fernandez-Pardo continues in attack after making his full debut at Elland Road but Steur and Willock bring a fresh look to the midfield.
Newcastle United: Lukáš Horníček, Lewis Hall, Sven Botman, Yoane Wissa, Harvey Barnes, Malick Thiaw (c), Sean Steur, Matias Fernandez-Pardo, Jacob Murphy, Joe Willock, Lewis Miley
Substitutes: Nick Pope, Fabian Schär, Aladji Bamba, Bazoumana Touré, Kyran Thompson, Miodrag Pivaš, Vakhtang Salia, Mason Miley, Michael Mills
